Marijuana’s journey from “reefer madness” to a mainstream product on store shelves is taking another historic step in Michigan this week.

The state licensing office, called the Marijuana Regulatory Agency, is set to begin accepting recreational marijuana business applications at 12:01 a.m. on Nov. 1.

Hand-delivered applications may be dropped off at the agency’s counter in Lansing beginning at 8 a.m. Friday.

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Gus Burns ~ Mlive.com ~